For the survival and normal functioning of a cell and ultimately of the whole organism, conservation and protection of the native DNA sequence and structure is necessary. However, our bodies are constantly exposed to diverse types of genotoxic insults from various sources that can damage cellular DNA and threaten the survival. In order to maintain genomic integrity, eukaryotic Cells have developed intricate DNA damage sensing and repair mechanism that combats the diverse sources of DNA damage and ensures survival. The signalling responses that are triggered following DNA damage from endogenous or exogenous sources give rise to a pathway called DNA Damage Response (DDR) pathway. The DDR pathway has evolved to be a complex, yet sensitive, highly integrated and interconnected pathway. OMICS group publishes articles involving many subjects like Pharmacy, Life sciences, Engineering, Medical, Management and Clinical. Each of the above mentioned department publishes all the major kinds of articles which include; research, review, mini-review, short communication, case report etc.
Last date updated on July, 2014