For the survival and normal functioning of a cell and ultimately of the whole organism, conservation and protection of the native DNA sequence and structure is necessary. However, our bodies are constantly exposed to diverse types of genotoxic insults from various sources that can damage cellular DNA and threaten the survival. In order to maintain genomic integrity, eukaryotic Cells have developed intricate DNA damage sensing and repair mechanism that combats the diverse sources of DNA damage and ensures survival. The signalling responses that are triggered following DNA damage from endogenous or exogenous sources give rise to a pathway called DNA Damage Response (DDR) pathway. The DDR pathway has evolved to be a complex, yet sensitive, highly integrated and interconnected pathway. OMICS Group through its Open Access Initiative is committed to make genuine and reliable contributions to the scientific community. OMICS Group hosts over 700+ peer-reviewed journals and has organized over 3000+ International Scientific Conferences all over the world. OMICS International is has wide classification of journals and Molecular Biology is one of the important of them. Molecular Biology covers each and every aspect of gene studies from the very basic to the new advance.
Last date updated on July, 2014