Silk-elastin-like protein (SELP) is composed of a repeating aminoacid block naturally present a protein found in Bombyx mori (silkworm) silk (GAGAGS) and that of mammalian elastin (GVGVP). The SELP is structured from four silk blocks, seven elastin blocks, and one lysinesubstituted elastin block. The protein readily forms a stable hydrogel at concentrations of 4 wt% or higher as the temperature is elevated from 25 to 37°C. The biocompatibility of SELP has been investigated by the direct injection to guinea pigs subcutaneously and intradermally. No sign of significant, harmful immunological reaction or inflammation was observed. The SELP medical and pharmaceutical applications to tissue engineering have been studied as the injectable polymer and the drug delivery system.
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Last date updated on July, 2014