Recently, the telomerase expression has also been used, either alone or in the company of other immortalizing genes, to create genetically stable, nontumorigenic cell lines capable of apparently
indefinite proliferation. The introduction of SV40. Tag sometimes does not induce immortalization, but rather extends the in vitrolife span of cells. This event reflects the critical attrition of telomere length, and can be overcome by expressing the catalytic component of the enzyme telomerase (human telomerase reverse transcriptase: hTERT). However, established cell lines frequently exhibit different characteristics from the primary cells, especially in terms of cell growth.
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Last date updated on July, 2014