The transplantation of hepatocytes, which has been proposed as temporary metabolic support in patients awaiting liver transplantation or spontaneous reversion of liver disease, is an attractive alternative to liver transplantation. Our group demonstrated the reversible immortalization of human hepatocytes. A highly-differentiated cell line, NKNT-3, was established via retroviral transfer. We performed intrasplenic transplantation of NKNT-3 cells treated with Cre recombinase (reverted NKNT-3 cells) into a rat model of liver failure.
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Last date updated on April, 2021