A tumor is an abnormal growth of body tissue. Tumors can be cancerous or noncancerous. The development of the new biological drugs in the treatment of cancer has recently renewed the concept of âtumor heterogeneityâ. The effects of the new targeted therapy, such as angiogenesis inhibitors and antivascular therapies, are more complex, compared to the well-known cytotoxic drugs. The intra- and inter-tumor heterogeneity, heterogeneity between metastatic disease, and also heterogeneity that happens over time, profoundly influence the treatment outcome of patients. At present, tailored medicine heavily relies on the pathological characterization of tumor by biopsies but we should have multiple biopsies of the same tumor in the same patients, to study the dedifferentiation of a metastatic disease under treatment.
Considering the invasive limitations and the issue of expression heterogeneity, molecular imaging, represent one of the most important and attractive challenge of Radiology. It allows non-invasive whole body characterization of in vivo tumor tissues by using multimodality imaging techniques (such as FDG-PET, non FDG-PET, DWI-MRI, Ultrasound targeted contrast Agents and Optical Imaging). All together, these techniques, offer a morphological and quantitative/functional imaging characterization, in a real time manner. They can be safely performed and repeated multiple times, providing information about heterogeneity in the primitive or metastatic disease. On the other hand, the future of molecular imaging is limited in terms of sensitivity, specificity and clinical translatability. The sensitivity is dependent on the molecular probes that are used and the specificity is dependent on the imaging signal obtained. Indeed, still few multimodality imaging techniques are applied in the clinical trials. In this view, we expect that the improvement of the technology behind molecular imaging, with a more availability and knowledge of the application of these techniques in the clinical settings, will definitely improve the diagnosis and the monitoring treatment in clinical cancer practice.
High impact factor for a particular journal implies good number of citations and quality of work. Because of the open access journals, impact factors are improving. Open access journal articles are essentially peer-reviewed and available for access through the directory of Open Access journals. Each open access journal delivers the latest updates in the respected research area in various formats so that subscribers can access the same through various options. With the growing number of scientific enthusiasts and readers by a large margin, the efficacy of open access publishing has witnessed an assertive impact. Robotics top journal is a Best journal which releases its issue in a Quarterly manner. In the year 2011, Robotics top journal was started by OMICS International which has huge success rating, from the day Robotics top journal got started in the OMICS International. Robotics top journal in the OMICS International presents in science field, best and updated articles which are very worthy in their research, review articles. In recent years, Open Access is the format of providing unlimited access via the Internet to peer-reviewed scholarly journal papers. The articles in Open access journal can be obtained more quickly than the one in conventional journal. Moreover the manuscripts can be published fast for Open Access. The last but not least, the number published paper is not unrestricted generally, because the papers is published by electrical version without printed version.
Last date updated on July, 2014