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Pharmacology and Toxicology of Anesthetics Adverse effects
It's a remedial strategy for cancers including pancreatic to inhibit proteasome exertion. Disulfiram( DSF) may bind copper ( Cu) to form a DSF – Cu complex. DSF – Cu is able of converting apoptosis in cancer cells by inhibiting proteasome exertion. DSF is fleetly converted to diethyldithiocarbamate( DDTC) within bodi.. Read More
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Role of Engineered Nanoparticles in Renal Toxin Assessment
A order is considered as the secondary target organ of nanoparticle( NP) toxin. Since it's the primary organ of excretion, NPs are anticipated to negatively affect the renal system. thus, a comprehensive review of recent knowledge on renal toxin of finagled nanoparticles( ENPs) was made. Mechanistic paradigms of their toxin have.. Read More
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Introduction: Plastics are now the most widely used man-made substances and have become omnipresent in every aspect of our lives. From medical supplies and water bottles to food packaging, clothing, and construction materials. Discarded plastics play important role as breeding places for mosquitoes as vectors of different diseas.. Read More
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A brief overview to systems biology in toxicology: The journey from in to vivo, in-vitro and omics
Toxicology aims to comprehend and envisage the adverse outcomes of chemicals and xenobiotics on the biological system. Predicting toxicity on the biological system is a complex and immense process. In-vivo, in-vitro, pre-, clinical and –omics level experimental approaches have been utilized to describe the toxicological im.. Read More
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Aflatoxins (AFs) are polyketide-derived; cancer causing toxic fungal metabolites (mycotoxins) produced by filamentous fungal species Aspergillus flavus, Aspergillus parasiticus, Aspergillus pseudocaelatus, Aspergillus pseudonomius and rarely Aspergillus nomius in/on foods and feeds, exclusively in field corn and peanuts. AFs fre.. Read More
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Toxicological and clinical data for the tolerability and safety of Ginkgo biloba leaf extract
Ginkgo biloba is one of the most widely used herbal remedies in Europe and the US. It may be purchased in different types of formulations, but most of the clinical studies have been performed with the controlled G. biloba extract. Indications include Alzheimers disease, cardiovascular disease, dementia, memory loss, and cerebral.. Read More
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Toxicology: Nanoparticles Toxicology in Drug Delivery
Nanoparticles have revolutionized biomedicine especially in the field of drug delivery due to their intriguing properties such as systemic stability, level of solubility, and target site specificity. It can, however, be both beneficial and damaging depending on the properties in different environments, thus highlighting the impo.. Read More
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Water contamination of Heavy Metal and Its Toxicity
Water is a source of life but contamination of water is the major threat in today’s India. The multiplicity of heavy metals, some of them are potentially toxic and are relocated to the surrounding Water environment through different pathways. Water quality has become a major issue due to growing industrial development, urb.. Read More
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Human reproduction and development is a succession of symbiotic events. Nearly, at every point of this phenomenon found to be the principle target of one or more reproductive toxicants. Chemical agents, physical factors, as well as biological intruders can pose antagonistic effects on reproductive potential of an organism. The p.. Read More
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Toxicology of Anti-Diabetics Drug
Diabetes mellitus is the century's epidemic and diabetes continues to increase at an early phase without appropriate diagnostic techniques. Data shows that about 1 in 4 persons with this illness are unaware. Type 2 diabetes is defined as relative insulin deficiency caused by β-cells (present in the pancreas) dysfunction. It.. Read More
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Skin toxicology: There Models in Toxicology
Our skin is exposed daily to substances; many of these are neutral and safe but others are potentially harmful. In order to estimate the degree of toxicity and damage to skin tissues when exposed to harmful substances, skin toxicology studies are required. If these studies are coupled with suitably designed mathematical models, .. Read More
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Background: Ingestion of copper sulphate is a common mode of poisoning in the Indian subcontinent. Cases are mainly suicidal in nature. The clinical course of the copper sulphate intoxicated patient is often complex involving intravascular hemolysis, jaundice and renal failure. The treatment is mainly supportive. Mortality is qu.. Read More
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Introduction: Organo Phosphorus Poisoning (OPP) remains a detrimental health problem in many parts of the world particularly in developing countries. The treatment did not change since many years, despite the increasing complications and case fatalities of the exposure. Separate clinical trials were conducted to test, if sodium .. Read More
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Treatment of Arsenic Toxicity during APML Treatment in a Pediatric Patient
A 17-year-old healthy female was presented with altered mentation after a fall. The workup revealed a new onset of APML. Chemotherapy was initiated. She developed MODS requiring ECMO and CVVHDF. Two days after discontinuation of support, the patient developed acute worsening mentation, emesis, diarrhea, tachycardia, fever, creat.. Read More
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Failure to Protect: Do Sunscreens Prevent Skin Cancer in Humans?
According to the Food and Drug Administration, the current scientific literature does not support the safety of organic sunscreen actives currently approved for use in the United States. Furthermore, the International Agency for Research on Cancer cannot find definitive proof that sunscreens prevent skin cancers. The concept tha.. Read More
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This study was carried out to investigate the oxidative stress status of colorectal cells of rats exposed to Cycas circinalis leaf powder and the ethanol extract separately. Seven (07) groups of five (5) rats each were used for this study. Group 1 rats were maintained on normal rat feed without cycas leaf powder or the extract (.. Read More
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Subacute Oral Toxicity Studies of ZingiVir-H: A Herbomineral Antiviral Drug in Wistar Rats
Herbal and herbo-mineral preparations are being traditionally used in Indian system of medicines. These preparations have numerous health benefits that have been involved in their widespread use for the treatment of different diseases/disorders by traditional Ayurvedic medicinal practitioners. However, to the best of our knowled.. Read More
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In this case report we present a young, healthy male, presenting to hospital 5 days after ingesting Roundup®, a glyphosate-containing herbicide. His main complaints included haematemesis, pleuritic chest pain and dyspnoea. Initial assessment revealed a Left Pneumothorax (PTX) for which an intercostal drain (ICD) was inserte.. Read More
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A Review on the Sex Difference in Lipotoxicity in Peripheral Nerves
Obesity is caused as the consequence of positive energy balance, which increases the amount of lipid in adipose tissue. The intake of excessive amounts of fatty acids is considered to be a risk factor for cardiovascular diseases, insulin resistance, dyslipidemia, and obesity. Males and females experience many diseases and disord.. Read More
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Aim and objective: The present study focuses on the toxicity of Para Phenylene Diamine (PPD) and case control study having intake of PPD orally. Further epidemiology of the PPD in Bahawalpur region is also discussed briefly. Study design: Case control study is involved as well as epidemiology of PPD given concisely. Methodolog.. Read More
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