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Chemicals such as herbicides used in agriculture, can be a source of soil and ground water pollution. Computer simulation models provide an efficient and cost-effective alternative that can be easily adapted to many field situations with varying soil types and different land uses. In the present study HYDRUS-1D and modified PRZM.. Read More
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The chemical composition, antioxidant and antimicrobial potentials of essential oils and oleoresins obtained from dill (Anethum graveolens L.) seeds and leaves have been studied. The isolated essential oils and oleoresins were analyzed by gas chromatography coupled with mass spectrometry. The antioxidant activity of essential oi.. Read More
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Guinea pigs are the most frequently used animals in phototoxicity studies. However, general toxicity studies most often use Sprague-Dawley (SD) rats. To shortening of the study period and to reduce the number of animals needed for drug development, we examined whether skin phototoxicity studies could be performed using SD rats. .. Read More
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Monitoring and Control of Exposure to Buprofezin in Greenhouses
The aim of this study was to assess dermal and respiratory exposure of workers to Buprofezin during spraying and during stapling of previously treated ornamental plants in greenhouses. Eight workers were monitored. A combination of hand washing and pads placed on the skin was used to evaluate actual skin contamination. The effic.. Read More
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Objective: Methamphetamine (METH) is a highly addictive substance abused world-wide in both males and females. Preclinical studies in male rodents suggest that large-dose exposure to METH can lead to persistent neurotoxic consequences to various brain regions. However, little research has focused on the potential role of sex in .. Read More
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In Vitro Photochemical Induction of Kojic Acid-DNA Adducts
Objective: Kojic Acid (KA) is a natural substance which inhibits skin melanin production and, when used alone or in combination with other compounds, is effective in reducing pigmentation in melasma patients. KA was classified by IARC as presenting limited evidence of carcinogenicity based largely on a single study showing thyro.. Read More
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Immunotoxicity of Zinc Oxide Nanoparticles and Municipal Effluents to Fathead Minnows
The presence of nanoparticles in sewage water has raised concerns about the cumulative toxicity of municipal effluent to aquatic organisms. The purpose of this study was to examine the effects of dietary zinc oxide nanoparticles (nano-ZnO) and ZnCl2 (at 100 ng total Zn/g food) in adult fathead minnows Pimephales promelas during .. Read More
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Objective: Present study was aimed to study the cytopathological effects of almix herbicide in Indian freshwater teleost, Oreochromis niloticus (Linn.) both under field and laboratory exposure. Methods: O. niloticus (Linn.) was exposed to almix herbicide at sublethal concentrations of 8 g/acre and 66.67 mg/L under field and lab.. Read More
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Electro-Oxidation and Detection of Phenol on Metals Modified Carbon Paste Electrodes
A variety of electrodes based on the modification of the carbon paste electrode by various metals such as, Ti, Natural phosphate (NP), kaolin, were prepared. Cyclic voltammetry and square wave voltammetry tests were performed to evaluate the electrochemical performance. The results confirmed that the modification of cabon paste .. Read More
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Use of systematic reviews (SRs) as a tool to facilitate evidence-based toxicology (EBT) assessments is increasing, though the field has yet to develop an appreciation of the rigor required to appropriately utilize this tool. Toxicologists should recognize the weight of the term, understanding that a systematic review involves fa.. Read More
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Objective: This study was undertaken to explore relationships between level of imidacloprid in the serum and semen quality among men farmers in addition to investigating histopathological findings in treated mature male rats. Methods and results: Our research entailed two parts; firstly, human part done on farm workers (n=35) w.. Read More
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Pesticides affect several human organs, resulting in a wide variety of physiological changes. In context with the occupational pesticide sprayers it is important to understand the influence of toxic exposure on human health. The present study is a comparative analysis of hematologic parameters, hepatic and renal function in the .. Read More
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Lack of Association of Paraoxonase 1 Promoter Polymorphisms with Gulf War Illness
Low serum PON1 levels are associated with Gulf War Illness (GWI). We sought to investigate the role of PON1 promoter polymorphisms in defining PON1 levels in GWI. There were no differences in the distribution of the PON1 -108 or PON1 -909 genotypes between the Gulf War Veterans (GWV) and the controls; however, PON1 activity and .. Read More
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Subacute methotrexate (MTX) encephalopathy is poorly understood. We performed a historical cohort study of all cases of subacute MTX encephalopathy at Lucile Packard Children’s Hospital from January 1, 2005, to December 31, 2011. Of 272 patients receiving MTX, 21 patients were diagnosed with subacute MTX encephalopathy. Ni.. Read More
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Tolerance of Tyrosine Kinase Inhibitors among 33 Cancer Patients Followed in CHU Annaba-Algeria
Background: The Inhibitors of Tyrosine Kinase are new targeted therapy recently explored with an aim of increasing the selectivity of antitumor action, the main objective was to evaluate the tolerance with the Inhibitors of Tyrosine Kinase among cancer patients. Material and Methods: A descriptive and retrospective study was ca.. Read More
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Zearalenone Induced Cytotoxicity and Oxidative Stress in Human Peripheral Blood Leukocytes
Zearalenone (ZEA) is a non-steroidal estrogenic mycotoxin produced by a variety of Fusarium fungi that are commonly found in feed. ZEA cause reproductive disorders of farm animals and occasionally hyperoestrogenic syndromes of humans; also, has been shown to be hepatotoxic, genotoxic, hematotoxic and immunotoxic, evidence primar.. Read More
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Toxicity Effects of Both Alum and Poly-DADMAC on Nubian Goats Evita
Nubian goats were the animals tested for the toxicity of both alum and polydadmac blend of 1% alum and 1% polydadmac at 1:2 Clinical signs of tested goats showed interrupted salivation, vomiting, watery diarrhea, dullness, inappetance ,inability to move accompanied by hind limb paralysis and finally recumbency. On postmortem, an.. Read More
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