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Purpose: Alpha-7-nicotinic acetylcholine receptor (α7-nAChR) positive allosteric modulators (PAMs) are a potential disease modifying treatment for Alzheimer’s disease, as exemplified by the approved drug galantamine. However, clinical development of this class of compounds has stalled due to poor efficacy and severe a.. Read More
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This research assessed the antioxidants and anti-inflammatory activities of methanolic, ethyl acetate and petroleum ether extracts of the stem bark of Heisteria parvifolia. The phytochemical screening identified several important phytochemical constituents among the various solvent used. The various extracts were also tested for.. Read More
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A large percentage of schizophrenic patients respond poorly to antipsychotic treatment. This could be explained by inefficient drug transport across the blood-brain barrier due to ABC efflux transporter, in particular, P-glycoprotein, mediated efflux. P-glycoprotein (P-gp) activity and expression in the blood-brain barrier can b.. Read More
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Determining Sucrose Concentration in Syrups by Pharmaceutical Methods
Background: Pharmaceutics is an essential branch of pharmacy which deals with the formulation and method development. Syrups are essential pharmaceutical preparations that often used for the pediatric patients as solid dosage forms are not practical in this population. Objective: The main aim of this experiment was to develop a.. Read More
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Background: The increasing number of available drugs and drug users, as well as more complex drug regimen leads to more side effect and drug interaction and complicates follow-up. A drug related problem is any undesirable event experienced by the patients which involves, or is suspected to involve, drug therapy, and that interfe.. Read More
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Antioxidant, analgesic and antidiarrheal activities of Litsea monopetala (LM) leaves extracts were investigated in order to assessment of pharmacological activities. In vitro antioxidant properties, in vivo analgesic and antidiarrheal activities were investigated in this study. Antioxidant plays a remarkable role to protect diff.. Read More
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Background: In this study was tried to evaluate the in vitro antimicrobial, thrombolytic with cytotoxic activity and in vivo anti-diabetic and lipid lowering activity of different fraction of methanolic extract of Solanum melongena which is widely used in the folkloric treatment in Bangladesh. The aim of this study was to find o.. Read More
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Ganglionated Plexus (GP) is a complex neural network composed by intrinsic cardiac autonomic nervous system (ANS) and is mainly located in fat pads around the antrum of the pulmonary veins (PVs). Recent studies demonstrated hyperactivity of GPs and atrial fibrillation (AF) formed a vicious cycle, to be specific, hyperactivity of.. Read More
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Sezary Syndrome and T–Cell Lymphoma
Lymphoma is a cancer of the white blood cells; the body has two main types of lymphocytes: B lymphocytes, or B-cells, and T lymphocytes. T-cell lymphoma is a disease in which T lymphocyte cells become cancerous. One of the most common forms of T-cell lymphoma is cutaneous, or skin, lymphoma, because it starts in the lymphocytes .. Read More
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Effect of Carvacrol Tested on Different in vivo and in vitro Experimental Studies: Systematic Review
The objective of the study was to show carvacrol isolad in in vitro and in vivo assays to verify the effects of their dosages on different application areas. The searches were realized in the following databases, pubmed, and academic google using the descriptors carvacrol; carvacrol and in vitro; carvacrol and in vivo. Thus that.. Read More
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Introduction: Therapeutic equivalence of medications is carried out through in vitro and in vivo studies called bioequivalence studies. Objective: To determine the in vitro therapeutic equivalence of the 5 mg glibenclamide multi-source tablets respecting the reference medicine. Materials and methods: Both, the multi-source dru.. Read More
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Pharmacogenomics: The Scientific Basis of Rational Drug Development and Prescribing
“It is more important to know what sort of a patient has a disease than what sort of a disease a patient has” (Hippocrates 460 BC-370 BC). The holy grail of drug discovery is to ensure that an individual responds positively to an investigational drug with minimal or no adverse events. This could then translate to ne.. Read More
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Background: This study deals with the comparative in vitro dissolution and in vitro disintegration characteristics of different brands of ranitidine hydrochloride film coated tablets most commonly available in Bangladesh which reflects the in vivo study. The objective of this present study was to evaluate the in vitro kinetic st.. Read More
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The Use of H2-Blockers in Intensive Care
Treatment plan for a patient in ICU is quite complicated as doctors from different specialities take part in it with advanced methods and machines. But the intensive treatment and diseases of the patient also has complications in itself... Read More
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Background: Although Extended Release (ER) dosage forms are not suitable for administration via Nasogastric Tube (NGT), they are used in critically ill patients. The aim of this study is to compare pharmacokinetics of intact and crushed ER theophylline capsules and tablets. Methods: Open-label, randomized controlled trial wit.. Read More
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Background and aim: Cancer patients treated with doxorubicin are at high risk to develop cardiotoxicity and hyperglycemia. The present study was designed to compare the effect of the two anti-hyperglycemia drugs; metformin and Sitagliptin, in the prevention of doxorubicin-induced cardiotoxicity in rats. Methods: Cardiotoxic.. Read More
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Commercializing Biosimilar: Challenges, Strategies and Finding Path to Success
Biosimilars and reference biologics have the same amino acid sequences. Differences in clinically inactive components are generally quite minor. Developments of Bio similar involve a series of complex decision and anyone of which have significant impact on Organization success. Early risk identification allows companies to p.. Read More
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The study aims to determine changes of Natamycin content in some dairy products (cheese-yoghurt) from different local companies in refrigeration conditions (4ºC ± 2ºC) or different temperatures (25ºC ± 2ºC , 40ºC ± 2ºC) and during exposure to sunlight at room temperature (25&ord.. Read More
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In this review/research article the effect of supplementation of bioavailable calcium to treat or eliminate osteopenia and osteoporosis has been discussed. Various aliments which can be corrected through supplementation of the bioavailable calcium have been documented. The transport of bioavailable calcium (both active and.. Read More
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Aim: The aim of this study is to investigate the influence of bile salts, sodium cholate, sodium 12-ketocholate and sodium dehydrocholate, as excipients in ranitidine, aminophylline and phenobarbital tablets on dissolution rate. Methods: Four groups of tablets (control without bile salts and three investigational groups contain.. Read More
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