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Objective: This study was designed to investigate intranasal lavage with a hypochlorous acid solution in the reduction of symptoms in the ambulatory COVID-19 patient. Study design: Study was a prospective, open-label, therapeutic intervention versus standard-of-care to evaluate patient-assessed improvement of clinical signs and.. Read More
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Long COVID syndrome, known as Long COVID, refers to a series of debilitating symptoms that arise after infection with the SARS-CoV-2 virus. These symptoms are similar to those experienced by some people after vaccination with vaccines based on mRNA platforms (Pfizer, Moderna). With more than 200 million Long COVID patients world.. Read More
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SARS-CoV-2: Dissecting the Puzzle of a Global Pandemic in 2019
The virus responsible for the COVID-19 pandemic, SARS-CoV-2, is thought to have originated in bats and spreads predominantly through respiratory droplets and contaminated surfaces. Symptoms can range from mild to severe and elderly adults and those with underlying health conditions are at greatest risk. The global response has i.. Read More
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A Prospective, Single-Center, Randomized Phase 2 Trial of Etoposide in Severe COVID-19
The systemic inflammatory response seen in patients with severe COVID-19 shares many similarities with the changes observed in Hemophagocytic Lymphohistiocytosis (HLH); a disease characterized by excessive immune activation. Many patients with severe COVID qualify for a diagnosis of HLH. Etoposide, an inhibitor of topoisomerase .. Read More
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The pandemic of COVID-19 has affected millions of people worldwide over the past three years, yet no effectivetreatment has been developed to cure the patients. This article published in Technology and Healthcare summarized the existing treatment options from both traditional Chinese medicine and Western medicine. Moreover, the .. Read More
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Background: The outside input COVID-19 epidemic is an important issue for studying the prevention and disease control measures and the spread of the COVID-19 epidemic. Following our previous study for the mainland China epidemic during December 31st 2021 to December 6th 2022, this paper studies the foreign input epidemics in Sha.. Read More
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Globally, viral infections continue to affect people of all ages, genders, and ethnicities resulting in substantial morbidity and mortality. The COVID-19 virus and its variants exhibit asymptomatic to severe pathological symptoms involving tissue/organ-based complications leading to fatality, which is a particularly noteworthy h.. Read More
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Background: Healthcare-associated bacteremia is a real public health problem because of its high morbidity and mortality. The objectives of this study were to describe the characteristics of bacteremia and to identify death – associated factors. Methods: This was a retrospective, descriptive and analytical study based on .. Read More
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Infection-Induced cAMP-Independent Regulation of Protein Kinase A (PKA)
The regulation of cellular signaling pathways is crucial for maintaining cellular equilibrium and coordinating responses to parasite infections. Protein Kinase A (PKA) is a key player in cellular signaling involved in regulating these processes. Apicomplexa parasites, including Plasmodium falciparum and Theileria annulata, explo.. Read More
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Background: Infectious bursal disease is a contagious viral infection that primarily affects young chickens and can cause significant morbidity and mortality. Vaccination with live attenuated infectious bursal disease viruses has been used to prevent the disease. The primary mechanism of the protective immune response in infecti.. Read More
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Background: This study describes an AIDS patient with CNS tuberculosis and cytomegalovirus infection that experienced IRIS associated with cytomegalovirus encephalitis and PTB while receiving ART. Case presentation: A 59-year-old male was referred to our hospital with a fever of unknown origin and paroxysmal cough as the main s.. Read More
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With the rapid spread of the novel Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2), the causative agent of COVID-19 pandemic, poses a serious threat to global public health and still requires further investigations into potential therapeutic agents. The availability of SARS-CoV-2 genomic data and efforts to determi.. Read More
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Linear Regression Analysis of COVID-19 Time-Series Data using the Gumbel Distribution
This study uses the Gumbel distribution to model and analyze the daily number of COVID-19 deaths in 8 European and North American countries, as well as in the 7 NHS regions of England, during the first wave of the COVID-19 outbreak. Linear regression is used for parameter estimation and data fitting. The analysis focuses on the .. Read More
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A Case Report on Rare Tumour of Renal Squamous Cell Carcinoma and its Associated Risk Factors
Background: Primary renal pelvic SCC is exceedingly rare neoplasm and poor prognosis. We reported a patient who underwent surgery for radical nephrectomy. Case: The patient was a 72-year old man, who visited doctors with complaints of dull aching in right flank region and occasional gross hematuria. Abdominal contrast-enhanced .. Read More
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Orally or intravenously administered antibiotics have been successfully reformulated for delivery via inhalation and treatment of serious, chronic lung infections. Oral clofazimine has shown microbiological efficacy in patients with pulmonary nontuberculous mycobacterial (NTM) disease, a condition that is increasingly prevalent .. Read More
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Background: Analysis of the antibiotic resistance and clinical features of clinical bacterial and fungi isolates from the lower respiratory tract of patients infected with COVID-19. Methods: Collected the qualified lower respiratory tract 397 strains of patients infected with COVID-19 between 10 December 2022 and 10 January 202.. Read More
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The number of platelets in SFPR patients decreased significantly, however, in the study by Zhao, et al., Platelet- Large Cell Ratio (P-LCR), Mean Platelet Volume (MPV), platelet distribution width (PDW) of the SFPR patients increased significantly, indicate increased platelet volume and platelet activation, which broadened the s.. Read More
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Salivary Amylase: A Monitoring Index for Respiratory Infectious Virus Contamination
Contact infection is a common route of respiratory infections, including that caused by severe acute respiratory syndrome coronavirus 2. Monitoring of viral contamination of environmental surfaces is critical for implementing appropriate hygiene measures and reducing the risk of viral transmission. We assessed the novel utility .. Read More
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Association between the Level of HbA1C and Prognosis of COVID-19 in Diabetic Patients
Objective: To determine the association between the HbA1C level and prognosis of COVID-19 in diabetic patients. Aim: SARS-CoV has emerged as a major economical and health crisis in the modern world. New strains and diverse clinical cases possess management challenges. As diabetes is found to be common comorbidity among the COVI.. Read More
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Synthetic Control and Comparative Studies on COVID-19 Vaccines Enrollment and Hesitancy in Africa
The COVID-19 pandemic has highlighted the importance of vaccines in the fight against infectious diseases. However, the rollout of vaccines in Africa has been slow and uneven. This study uses synthetic control and comparative analysis to examine the factors that have contributed to differences in vaccine enrollment in African co.. Read More
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