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Recent advances in the design of both viral and non-viral gene delivery vehicles have allowed for more efficient and selective delivery of therapeutic genes to tumor cells leading to greater and longer term gene expression.In addition, a more realistic assessment of how genetic material most likely produce the greatest anti-tumor effect when expressed from within only a portion of cells in the tumor has resulted in the evolution of vectors that have demonstrated anti-tumor effects in the clinical setting and will likely result in approved therapies that can truly benefit the patient population.
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