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The presence of cell-free fetal DNA in the plasma of pregnant women has opened up the possibility of noninvasive prenatal diagnosis. With the advances in molecular techniques of microfluidics and massive parallel sequencing, an increasing number of fetal genetic diseases/conditions can be noninvasively detected using maternal plasma DNA analysis. Remarkably, it has recently been shown that the genome-wide genetic map of an unborn fetus can be constructed through extensive sequencing of maternal plasma DNA.
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