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Standard chemotherapy for adults with AML (Acute Myeloid leukemia) can induce remission but is not curative for the majority of patients who will eventually relapse and die of their disease. Immunotherapy represents a potentially efficacious adjunct to standard AML therapy, particularly for those in the Minimal Residual Disease (MRD) state during which immune-based therapies may be most effective. Unfortunately, the efficacy of cancer immunotherapy has been limited by a number of immune evasion pathways which suppress anti-tumor immunity and enable tumor progression. A major focus of our research group has been to characterize immune evasion pathways promoted by AML with the ultimate goal of blocking such pathways to unleash the full effectiveness of immunotherapy for leukemia.
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