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Hepatocellular Carcinoma (HCC) is ranked the third most common cause of cancer-related deaths worldwide, and each year, approximately 750,000 new cases are diagnosed. Bruix and Sherman emphasized the need for effective surveillance system in order to gauge the magnitude of the anticipated burden of the disease. The frequently cited source of information on the worldwide incidence of major types of cancer is the GLOBOCAN. The information provided highlighted the global variation in the incidence of HCC with the highest incidence clustering in developing countries with 55% in China. This worldwide variation in the incidence of this disease can be attributed to variations in the distributions of risk factors. In most HCC cases, patients are initially affected with liver cirrhosis. The key risk factors for liver cirrhosis are the hepatitis B and C infection. Other documented risk factors are smoking, gender, age, obesity, and diabetes, through their associations with nonalcoholic fatty liver disease (NAFLD).
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