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Hemolytic Anemia is very common during pregnancy especially in malaria endemic areas. It often associated with Tropical Splenomegaly Syndrome (now commonly known as Hyper-Reactive Malarial Splenomegay), which is an autoimmune phenomenon that follows episodes of malaria in the past. Very few cases of Coombs Negative Hemolytic Anemia have been reported in literature . This condition has not yet been described in Sub-Saharan Africa; hence we are presenting the first such case.
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