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Primary myelofibrosis (PMF) is a myeloproliferative neoplasm characterized by stem cell derived clonal myeloproliferation and extramedullary haematopoiesis (EMH). Myelofibrosis can present as a de novo disorder or evolve secondary to previous polycythemia vera or essential thrombocythemia (post PVMF or post ETMF) [1]. Primary myelofibrosis (PMF) is the least frequent among the chronic myeloproliferative diseases.
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