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The functional status of lymphocytes is tightly linked to metabolism as glycolysis and mitochondrial respiration supply lymphocyte activation with necessary intermediates. It is currently accepted that resting lymphocytes such as naïve or memory T cells utilize oxidative phosphorylation for ATP production. Following activation, metabolism in T cells switches from catabolic to aerobic anabolic glycolysis and glutaminolysis. This transition is similar to metabolic shift in tumor cells.
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