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Background: Recently,Neutrophil-lymphocyte ratio (NLR), Platelet-lymphocyteratio (PLR) and Mean platelet volume(MPV) have become increasingly useful as predictive and prognostic tools in patients with various medical conditions. To make for easy interpretation and application, the reference values of these parameters in healthy adults need to be established in our environment. Objectives: To establish the reference values for NLR, PLR and MPV in healthy adults in a tertiary health facility in the North-central Nigeria. Methods: Venous blood samples from five hundred (500) healthy adults were analyzed using a Sysmex automated haematology analyzer. The NLR and PLR were calculated while the MPV values were recorded from the print outs. The effects of some demographics on these parameters were assessed using the SPSS 19. Results: The mean value for NLR was 2.8 (reference range, 1.2-4.4), PLR was 137 (reference range, 75-199) and MPV was 10.6fl (reference range, 9.7-11.5fl)...Read more