Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Dendritic Cell Targets for Self-Replicating RNA Vaccines

Vaccination is the cornerstone for controlling many pathogen infections [1-8], and is also under scrutiny for cancer Immunoprophylaxis/immunotherapy [9,10]. Induction of both antibody and cell-mediated immune (CMI) defences is preferable for ensuring robust immune defence against most pathogen infections, although defence against certain pathogens may require a more dominant CMI response as exemplified by hepatitis C virus [11]. A major drawback of most current vaccines is their non-replicative nature [3,8], being inactivated or recombinant protein-based vaccines, limiting the amount of antigen available to the immune system. Replicating vaccines offer several rounds of antigen production to increase the efficacy of immune defence induction [3,8]. This replicative nature can mimic the situation with replicating pathogens, whereby antigen can be directed into both MHC Class I and MHC Class II presentation pathways, thus promoting humoral and CMI defences. These characteristics are also important for cancer vaccines, particularly when the immunogen in question is weak..read more

 

Figure   Figure

 

  • Share this page
  • Facebook
  • Twitter
  • LinkedIn
  • Google+
  • Pinterest
  • Blogger
Top