alexa Erythrocyte Phosphatidylserine Exposure in β-Thalassemia

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Erythrocyte Phosphatidylserine Exposure in β-Thalassemia

Introduction: Phospholipid asymmetry is well maintained in erythrocyte (RBC) membranes with phosphatidylserine (PS) exclusively present in the inner leaflet. Eryptosis, the suicidal death of erythrocytes, is characterized by cell shrinkage, membrane blebbing and cell membrane phospholipids scrambling with PS exposure at the cell surface. Erythrocytes exposing PS are recognized, bound, engulfed, and degraded by macrophages. Eryptosis thus fosters clearance of affected erythrocytes from circulating blood which may aggravate anemia in pathological conditions. Thalassemia patients are more sensitive to the eryptosis depletion and osmotic shock which may affect RBC membrane Phospholipid asymmetry. Aim: We aimed in this work to determine the erythrocyte PS exposure in splenectomized and non splenectomized..read more

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