Tuning NOTCH

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Tuning NOTCH

The emergence of multi-cellular organs and their organization into complex body plans is a major cornerstone concerning origin of life on Earth. This requires that the fundamental unit of life, namely the cell, must communicate, coordinate and organize. Cell communication mediated by signal transduction pathways is essential for the development and functioning of any organism. About 20 different signal transduction pathways are required to generate the high diversity of cell types, patterns and tissues characteristic of metazoans [1]. A major juxtacrine signaling system that allows cells to directly talk to each other to program almost every cell type in the body is characterized by the Notch more

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