alexa Ewing's Sarcoma as Second Malignancy after Bilateral Retinoblastoma

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Ewing's Sarcoma as Second Malignancy after Bilateral Retinoblastoma

Background: Children diagnosed with the hereditary form of retinoblastoma (Rb) have excellent survival, but face an increased risk of bone and soft tissue sarcomas. This predisposition to sarcomas has been attributed to genetic susceptibility due to inactivation of the RB1 gene as well as past radiotherapy for Rb. Objectives: To report the case of a child with hereditary form of bilateral RB, who developed Ewing’s sarcoma of the right femur 10 years after the Enucleation of the both eyes...read more

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