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Genetic variation in the interleukin 28B (IL-28B) region has been associated with sustained virological response (SVR) rates in patients with chronic hepatitis C (CHC) who were treated with pegylatedinterferon (PEG-IFN) and ribavirin (RBV). The aim of this study is to clarify whether changes in type 1 IFN receptor 2 (IFNAR-2) expressions by peripheral blood monocytes (Mo) are related to genetic variation near the IL-28B gene. Patients and Methods: One hundred and forty-eight CHC patients with genotype 1b and high viral load receiving PEG-IFN and RBV were studied. IFNAR-2 expression by peripheral blood Mo was measured as the mean fluorescence intensity (MFI) before and up to 28 days after starting therapy. Eighty-three of 148 patients consented to genetic investigation (IL-28B genetic variants in rs8099917)...read more
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