Sworn Enemies Living Together

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Sworn Enemies Living Together

Development of cancer in host either humans or other vertebrate animals has led to the establishment of statement by scientists and researchers involved in this field that it is a multi factorial disease (i.e. genetics, age, ethnic background, environmental factors, incidence of occurrence of specific bacterial and viral infections, exposure to certain drugs and chemicals and immunological status of the host etc.). Out of all these factors, immune system has the responsibility to take care of host against any external pathogen (i.e. bacteria, virus, parasites and fungi etc.) as well as xenobiotics including cancer causing agents (i.e. carcinogens). If anything foreign to the body enters into it, immune system comes in action within minutes via activation of innate immune response comprising of innate immune cells (i.e. Macrophages, Neutrophils, Dendritic Cells (DCs), Mast cells, Myeloid derived suppressor cells (MDSCs), Natural Killer (NK) cells) and its humoral component called complement system to clear it from the body using different fast and robust pathways. If innate immune system proves incapable to do that, then it sends signals (various effector molecules i.e. cytokines and chemokines) to activate adaptive immune response (comprised of T cell and B cell mediated immune response) more


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