Chemotherapy, as one of the primary treatments especially for advanced cancers, is blocked by drug resistance. Research on drug resistance in cancer has focused on cellular resistance due to both the specific nature and genetic background of the cancer cell itself, and the genetic or epigenetic changes that follow toxic chemotherapy, namely intrinsic resistance and acquired resistance. MiRNA was firstly demonstrated linking with cancer in 2002, Anti-oncogenes and precursor of oncogenes, functioning in cell progress as well as normal genes, are well known to play a critical role in cancers.
High-impact journals are those considered to be highly influential in their respective fields. The impact factor of journal provides quantitative assessment tool for grading, evaluating, sorting and comparing journals of similar kind. It reflects the average number of citations to recent articles published in science and social science journals in a particular year or period, and is frequently used as a proxy for the relative importance of a journal within its field. It is first devised by Eugene Garfield, the founder of the Institute for Scientific Information.The impact factor of a journal is evaluated by dividing the number of current year citations to the source items published in that journal during the previous two years.
Last date updated on July, 2020