|Translationally controlled tumor protein (TCTP), found both intracellular and extracellular milieu of cells, is expressed in most of organisms, including plants, animals and humans in which it is highly conserved. TCTP plays a multitude of biological roles in cellular processes, for example, the regulation of cell cycle, apoptosis, and malignant transformation. Extracellular TCTP has the cytokine-like histamine releasing activities (HRA). Parasites also actively secrete TCTP homologs and they are readily detected in the biological fluids of infected hosts. TCTP/ HRF homologs of parasitic origins also showed conservation of TCTP among various species. They play pivotal role in evading the host immune responses and in the development of parasitic diseases in host organisms.
The impact factor of journal provides quantitative assessment tool for grading, evaluating, sorting and comparing journals of similar kind. It reflects the average number of citations to recent articles published in science and social science journals in a particular year or period, and is frequently used as a proxy for the relative importance of a journal within its field. It is first devised by Eugene Garfield, the founder of the Institute for Scientific Information.The impact factor of a journal is evaluated by dividing the number of current year citations to the source items published in that journal during the previous two years.