|Infections associated with implanted medical devices such as joint arthroplasty prostheses are an increasing problem due to mounting antibiotic resistance/insusceptibility of common causative organisms, and increased requirement by a more numerous ageing population. Antibiotics are crucial for prevention of infection during joint replacement implantation procedures. Antibiotics are also the mainstay infection treatment option, in addition to debridement and removal of infected tissue and implanted biomaterials. Prosthesis and tissue removal is the most common and typically only option for curing an infection, resulting in serious health, social and economic consequences (increased morbidity, mortality, prolonged hospital stay). The strengthening of pre-clinical and clinical research is necessary to allow routine recommendation of bacterial extracts prescription for ARTI prevention in children.
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