|Autonomic Nervous System (ANS) dysfunction (AuD) is a common cause of disability in people living with Multiple Sclerosis (MS), but clinical manifestations are heterogeneous and therapeutic options are lacking. AuD is implicated as having a possible role in the regulation of inflammation and neurodegeneration. treatments with drugs that affect the ANS may have an impact in the inflammatory and neurodegenerative processes intrinsic to MS, resulting in an intriguing and potentially significant novel therapeutic consideration. AuD is a common cause of disability in MS patients, ranging from sphincter (bladder and bowel) dysfunction, to fatigue and cardiovascular autonomic dysfunction (CAD), among others. Both the sympathetic (SNS) and parasympathetic (PNS) nervous systems are frequently, albeit not always simultaneously, compromised.
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