One possibility is that adaptive cellular immunity impairs brain tissue regeneration and health in PD patients. Neuroinflammation including reactive gliosis invariably found following brain injury/insult, is associated with PD pathogenesis and progression. Sensory disorders including pain and other non-motor symptoms occur frequently in patients with Parkinsonâs disease. Cognitive and affective factors also influence the subjective experience of pain. Depression may be one of the leading factors contributing to pain. A logistic regression model between pain and variables was established to confirm the independent predictors of pain in patients with PD. One way T cells could impact PD-like symptoms is by altering the transit of T cells across the blood-brain barrier (BBB) independent of their antigen reactivity, which might also serve to enhance the extravasation of activated T cells reactive against but normally sequestered from normal brain components.
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Last date updated on January, 2021