|Parkinsonâs disease (PD) is a progressive neurodegenerative disorder that is most common in patients over 65 years old, occurs in people in the western hemisphere. PD is characterized by the progressive loss of midbrain dopamine neurons in the substantianigra, which causes motor dysfunction amongst other disorders. There is no cure for this disease currently, and dopamine replacement therapy has shown little efficacy. There has been growing evidence that adaptive immunity may play a role in PD progression as well as other neurodegenerative disorders including Alzheimerâs disease. T-lymphocytes have been previously implicated in protecting dopaminergic neurons in the substantianigra from induced cell death.
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