Aplastic anemia is a life-threatening pancytopenia with an incidence of two cases per million per year and a two-year mortality rate of 40%. Immune thrombocytopenia (ITP), previously known as idiopathic thrombocytopenic purpura, is now recognized as an immune-mediated platelet disorder that occurs more commonly in children than adults, with peak pediatric incidence of 4-6 children per year, often between two and five years of age. Orbital myositis is inflammation of the extraocular muscles that commonly affects young adults and children with a female predilection of 2:1. Amyloidosis refers to the deposition of insoluble fibrils in the extracellular spaces of organs and tissues. Bordetella pertussis, a Gram-negative coccobacillus, classically causes whooping cough in infants and young children. Blue rubber bleb nevus syndrome (BRBNS) is a rare congenital entity consisting of distinctive venous malformations in the skin and gastrointestinal tract that can result in bleeding and chronic anemia.
Scholarly peer review is the process of subjecting an author'sscholarlywork, research, or ideas to the scrutiny of others who are experts in the same field, before a paper describing this work is published in a journal. The work may be accepted, considered acceptable with revisions, or rejected. Peer review requires a community of experts in a given (narrowly defined) field, who are qualified and able to perform reasonably impartial review.
Last date updated on June, 2021