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Endocrine disorders constitute abnormality of one of the body’s endocrine glands. They are grouped into two categories: Endocrine disease that results when a gland produces too much or too little of an endocrine hormone, called a hormone imbalance. Endocrine disease that results due to the development of lesions (such as nodules or tumors) in the endocrine system, which may or may not affect hormone levels.