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Cardiovascular diseases have a high prevalence in developing and developed countries and myocardial infarction (MI) accounts for majority of deaths and disabilities. It therefore attracts continuing Research into the biomedical activities of marine natural products has led to the discovery of many potentially active agents consi.. Read More
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Rectal Drug Delivery System: An Overview
Rectal drug delivery is a viable alternative to oral and parenteral routes of administration for protein-peptide drugs, since it prevents first-pass metabolism and delivery. Rectal administration enables both local and systemic therapy of drugs. The rectal drug delivery system is a useful alternative for patients who cannot swal.. Read More
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Covid-19 and Vaccines Developed in India
Coronavirus represents Corona Virus Disease-2019 is a viral infection achieved by serious intense respiratory disorder Covid (SARS-CoV-2) announced as pandemic by World Health Organization (WHO) on 11 March 2020. Coronaviruses are the colossal gathering of infections comes from Coronaviridae, Arteriviridae, and Roniviridae famil.. Read More
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A Review on Corona Virus: Biology and Pathophysiology
The Corona Virus Disease (COVID-19) is quickly spreading across China and globally. In this Review article we can study about Biology and Pathophysiology of Corona virus. How the disease can spread from China to Whole world. It became clear that the COVID-19 infection occurs through exposure to the virus, and both the immunosupp.. Read More
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18-Glycyrrhetinic Acid Chalcones and Its Salts with Their Mass Fragmentation Pattern
This work reveals the synthesis of chalcones which are derived from 18β-glycyrrhetinic acid, through its keto derivative. First of all by means of Jones oxidation the hydroxyl group of glycyrrhetinic acid at position 3 oxidized to keto group. Then α, β-unsaturated ketones (enones) are produced when this keto group.. Read More
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Saxagliptin is an orally active, highly potent, selective and competitive dipeptidyl peptidase (DPP)-4 inhibitor used in the treatment of type 2 diabetes mellitus at doses of 2.5 or 5 mg once daily. The purpose of this study was to evaluate the bioequivalence and to investigate the pharmacokinetic properties of two formulations .. Read More
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Novelty and Compliance of Oral Fast Dissolving Thin Film A Patient Friendly Dosage Form
The oral fast-dissolving film is an advanced, patient compliant and novel delivery system. The acceptance of this ingenious dosage form is increasing day by day due to its several comparative advantages of being cost-benefit, rapid dissolving without water aid, as well as greatly compliant to both geriatric and pediatric patient.. Read More
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Use of Antimalarial Drugs in Covid-19
During the recent pandemic of SARS-Covid-2 has made the clinicians to use other drugs that are known to be effective for other medical conditions. Among these repurposed therapeutic agents are the antimalarial drug chloroquine and its analogue hydroxy chloroquine, which is used for the treatment of autoimmune diseases such as SL.. Read More
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Medicinal Importance of Garlic and Onions on Autonomic Nervous System
Garlic and onion have been of medicinal value in the treatment of hypertension and they are also used by people who wanted to lose weight. This research discusses the effects of these bulbs on the entire nervous system, mechanism of action, and complications of over use. This research highlights the chemistry of the active compo.. Read More
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Galactomannan Fiber and Alkaloids for Hyperlipidemia
Treatment and control of elevated LDL-C are as primary goals of CVD prevention in guidelines. Both epidemiological and experimental studies confirm the protective effect of high-density lipoprotein cholesterol (HDL-C) on the onset of CAD despite LDL-C level, owing to the reverse cholesterol transport process of HDL-C. However, i.. Read More
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Where simple, accurate, precise and rapid spectrophotometric method was developed for the assessment of mometasone furoate (MF) and tolnaftate (TF) in pure form and pharmaceutical preparations. These methods depend on the interaction between cited drugs with eriochrome black T (EBT), methyl orange (MO) and Chrome azurol S (CRS) .. Read More
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The anti-inflammatory and anti-arthritic activity of GN1 (6-hydroxymethyl-3-(1-methylene-allylamino)-tetrahydropyran- 2,4,5-triol), an analog of glucoseamine was investigated in the adjuvant induced arthritis (AIA) in rats. It was observed that the highly increased hind paw swelling was significantly reduced (p<0.001) with no.. Read More
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Search for newer plant derived medicinal is always on. Rose hip plant is the plant showing promising potential. Reverse pharmacology and transdisciplinary exploratory studies on rose hip are increasingly being studied these days. In this study seven group of animals were assessed with different dose levels were assessed for thei.. Read More
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The delivery of cancer drugs such as topotecan and doxorubicin poses risks such as off target tissue interactions and systemic toxicity. The use of thermosensitive liposomes provides a targeted manner to deliver such drugs with minimal risk, since drug release occurs upon administration of hyperthermia at the target site, such a.. Read More
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Uncontrolled hypertension is a major risk factor for cardiovascular disease; poor medication adherence and persistence have been identified as a significant contributing factor. To determine the level of patient’s persistence and adherence to antihypertensive drugs, diet, exercise and other socio demographic factors. A des.. Read More
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The aim of this study to trend the clinical treatment of clostridium difficile infected patient by oral vancomycin with lowering of patient risk through control of antibiotic's prescription in hospitals. Clostridium difficile is common cause in inflammation of colon, symptoms of abdominal pain/tenderness diarrhea, fever and coli.. Read More
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Zebra Fish (Danio rerio) Diving into Bipolar Disorder
Bipolar disorder is a chronic neurological disorder. It is the 6th major ailment which affect 1% of the world population. Lithium is the only classic drug available because the molecular mechanisms of remain unclear. It is difficult to establish in vitro adequate models for pathological analysis because of the heterogeneity of t.. Read More
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Effect of Oral Supplement “Lycopene” On Reducing the Signs of Skin Ageing
In today’s world physical appearance is important not only as a symbol of identity, but also as an indicator of health and youth and there is a growing awareness that beauty starts from within. This study was designed to evaluate the effect of a tomato based oral supplement formulation (Lycoderm) containing different phyto.. Read More
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Formulation of the Tazarotene Cutaneous Gel and Its Physicochemical Characteristics
Treatment of psoriasis is divided to three main types: moderate treatment (moisturizers, phototherapy and etc.), low treatment (changing the life style) and high treatment include systemic medications. Tazaroten is one of the most effective and the most applicable dermal medicine in treatment of two mentioned diseases that avai.. Read More
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The aim of the present study was to test an evidence-based functional food (FPP-ORI, Osato Research Institute, Gifu, Japan) on redox and immune system modulatory efficiency together with gut permeability in HRT-treated postmenopause women. The study population consisted of 74 postmenopausal women who were on hormone replacement .. Read More
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