alexa Restoration of PRG2 Expression by 5-Azacytidine Involves in Sensitivity of PKC-412 (Midostaurin) Resistant FLT3-ITD Positive Acute Myeloid Leukaemia Cells

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Restoration of PRG2 Expression by 5-Azacytidine Involves in Sensitivity of PKC-412 (Midostaurin) Resistant FLT3-ITD Positive Acute Myeloid Leukaemia Cells

Mutations in FLT3 receptor tyrosine kinase are the most frequently identified genetic event in acute myeloid leukemia (AML) that results in constitutive activation of survival and proliferation pathways including JAK/STAT, PI3K and RAS/MAPK pathways. The two major activating mutations in FLT3 gene are the internal tandem duplications (ITDs) of the juxtamembrane domain and the activation loop mutations of the tyrosine kinase domain . Thus, tyrosine kinases such as FLT3 represent an attractive therapeutic target for cancer therapies in AML. Several FLT3 tyrosine kinase inhibitors (TKIs) are currently under investigation including PKC-412.

 

 

Citation: Al-jamal HAN, Jusoh SAM, Sidek MR, Hassan R, Johan MF (2015) Restoration of PRG2 Expression by 5-Azacytidine Involves in Sensitivity of PKC-412 (Midostaurin) Resistant FLT3-ITD Positive Acute Myeloid Leukaemia Cells. J Hematol Thrombo Dis 3:186 doi:10.4172/2329-8790.1000186

 
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