Multiple myeloma (MM) is characterized by clonal proliferation of neoplastic plasma cells that secrete monoclonal immunoglobulin or M-protein. Prognosis in multiple myeloma is influenced not only by staging and patient factors but also by disease biology. Conventional cytogenetic studies and fluorescent in situ hybridization (FISH) are widely used currently to identify cytogenetic abnormalities and stratify MM into high risk, intermediate risk and standard risk categories. Recently, MYC gene related dysregulations, MYC over-expression and its role in prognosis has been studied in MM. MYC is a regulator gene located on chromosome 8 and it encodes for a transcription factor which plays a major role in cellular proliferation. MYC gene rearrangements in association with t (8;14), t( 8;22) and t (2;8) has been originally studied in 90% cases of Burkitt lymphoma.