alexa Digital Necrosis in Type I Cryoglobulinemia

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Digital Necrosis in Type I Cryoglobulinemia

A 69-year-old man presented with severe pain in hands and feet. The distal part of most fingers and toes were necrotic (Figure 1). Extensive diagnostic work-up was performed: physical examination was otherwise unremarkable, and a thoracic and abdominal CT-scan was non-contributive. Blood sampling demonstrated the presence of a type I cryoglobulinemia, constituted of a monoclonal immunoglobulin G kappa at a titer of 2.03 g/L. Bone marrow smear and biopsy were normal. Treatment with oral corticosteroids and rituximab was instituted, and necrotic lesions were surgically excised. Unfortunately, the patient was readmitted one month later for extension of digital necrosis and infectious pneumonia. Outcome was unfavorable and the patient died. Type I cryoglobulinemia represent 10 to 15% of all cryoglobulinemia [1]. They are frequently associated with malignant B cell proliferation and the production of a precipitating monoclonal immunoglobulin that may result in severe ischemic manifestations such as the one reported here..

read moreblood-lymph-Distal-part

 
  • Share this page
  • Facebook
  • Twitter
  • LinkedIn
  • Google+
  • Pinterest
  • Blogger
 
adwords