Guinea Pig

As per available reports about 100 journals, 162 conferences, 30 workshops are presently dedicated exclusively to Guinea Pig and about 366282 articles are being published on the current trends in Guinea Pig. In terms of research annually; USA, India, Japan, Brazil and Canada are some of the leading countries where maximum studies related to Guinea Pig are being carried out. As reported in “Influence of Oral Tolerance on Lung Cytokines Expression and Oxidative Stress Activation in Guinea Pigs with Chronic Inflammation” article by Samantha Souza Possa, et al. We had previously demonstrated that oral induced tolerance attenuates lung tissue hyperresponsiveness, eosinophil inflammation and extracellular matrix remodelling in a model of chronic inflammation in guinea pigs. In the present study, we evaluated if these responses were associated to alterations on Th1/Th2 cell expression on airways and distal lung. Animals received seven inhalations of ovalbumin (1-5 mg/mL; OVA group) or saline (SAL group) during 4 wk. Oral tolerance (OT) was induced by offering ad libitum ovalbumin 2% in sterile drinking water starting with the 1st inhalation (OT1 group) or after the 4th (OT2 group). After the last inhalation, lungs were removed for the histological analysis using morphometry. We assessed IL-2, IL-4, IL-13, IFN-γ and iNOS both in airways and distal lung. There was an increase in IL-2, IL-4, IL-13, IFN-γ and iNOS positive cells both in airways and alveolar septa in ovalbumin-exposed guinea pigs compared with controls (P<0.05). Both in airways and in lung tissue there was a decrease in IL-4, IL-13 and iNOS positive cells in OT1 and OT2 compared to OVA (P<0.05). Considering IL-2 expression, there was an increase in OT1 and OT2 compared to OVA (P<0.05). We observed positive correlations among the functional responses and some inflammation and oxidative stress pathway activation markers evaluated, especially in alveolar wall. Oral tolerance induces a shift in Th1/Th2 and influences oxidative stress activation both in airways and distal lung of animals with chronic pulmonary allergic inflammation. These results may clarify the mechanisms involved in the attenuation of mechanical responsiveness, inflammation and remodelling of airways and distal lung by oral tolerance, as previously shown in this animal model. The Journal of Allergy & Therapy is an academic journal – hosted by OMICS International – a pioneer in open access publishing – and is listed among the top 10 journals in Guinea Pig. Each year research scientists have noticed a rise in the number of congresses being held in this field.

The Journal of Allergy & Therapy provides a unique platform to researchers and scientist to explore the advanced and latest research developments in the field of Guinea Pig, Allergy & Therapy, thus bridging the gap between researchers and young scientists. OMICS International – a pioneer in organizing international conferences. The Journal of Allergy & Therapy is associated with our conference "3rd International Conference and Exhibition on Clinical & Cellular Immunology" (Immunology Summit-2014) to be held during September 29th - October 01st, 2014 at Baltimore, USA with a theme “From basic immune understanding to clinical breakthroughs”. The major sessions include Cellular Immunology, Neuro Immunology, Autoimmunity, Auto antibodies and Autoantigens, Caner Immunotherapy, Inflammation and many other.

OMICS Group hosts over 400 leading-edge peer reviewed Open Access Journals and organize over 300 International Conferences annually all over the world. OMICS International journals have over 3 million readers and the fame and success of the same can be attributed to the strong editorial board which contains over 30000 eminent personalities that ensure a rapid, quality and quick review process. OMICS Group signed an agreement with more than 500 International Societies to make healthcare information Open Access.