Reactive bone marrow plasmacytosis occurs in association with a variety of conditions, such as chronic infections, autoimmune diseases, connective tissue and chronic granulomatous disorders, diabetes mellitus, hypersensitivity states, drug-related agranulocytosis,
iron deficiency, megaloblastic and hemolytic anemia, hemopoietic and non-hemopoietic malignant diseases, angio-immunoblastic lymphadenopathy, and multicentric Castlemanâs disease .In such reactive cases, Plasma Cells (PCs) usually account for 10%-20% of cells
in bone marrow trephine biopsy sections and rarely exceed 50%. Chest X-ray and thorax Computed Tomography (CT) showed evidence of pneumonic infiltrate in the left lower lobe. After blood, urine, and sputum cultures were obtained, the patient was treated with imipenem 5 Î¼g/kg/day for febrile neutropenia and Granulocyte Colony-Stimulating Factor (G-CSF). Bone marrow aplasia associated with prominent atypical plasma cell proliferation (96% of all nucleated cells exhibited transient pancytopenia) and hypoplastic bone marrow.
Zafer Gokgoz, Prominent Reactive Plasmacytic Proliferation Presenting with Transient
Pancytopenia: An Unusual Case
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Last date updated on September, 2014