As per available reports about 3130 journals, 250 Conferences, 39 workshops are presently dedicated exclusively to Mass Spectrometry and about 33,100 articles are being published on the current trends in Mass Spectrometry. In terms of research annually, USA, India, Japan, Brazil and Canada are some of the leading countries where maximum studies related to Mass Spectrometry are being carried out. As reported in 33,100 articles, Mass spectrometry is an analytical tool used for measuring the molecular mass of a sample. For large samples such as biomolecules, molecular masses can be measured to within an accuracy of 0.01% of the total molecular mass of the sample i.e. within a 4 Daltons (Da) or atomic mass units (amu) error for a sample of 40,000 Da. This is sufficient to allow minor mass changes to be detected, e.g. the substitution of one amino acid for another or a post-translational modification. For small organic molecules the molecular mass can be measured to within an accuracy of 5 ppm or less, which is often sufficient to confirm the molecular formula of a compound, and is also a standard requirement for publication in a chemical journal. Structural information can be generated using certain types of mass spectrometers, usually those with multiple analysers which are known as tandem mass spectrometers. This is achieved by fragmenting the sample inside the instrument and analysing the products generated. This procedure is useful for the structural elucidation of organic compounds and for peptide or oligonucleotide sequencing.
Mass spectrometry is an analytical technique that helps in identifying the quanity and type of chemical substances present in a sample by measuring the mass-to-charge ratio and abundance of gas-phase ions. The main components of mass spectrometry includes ion Source, mass analyser and detector. Principles of mass spectrometry includes qualitative and quantitative analysis providing information about the mass of atoms and molecules, molecular structure determination of organic & inorganic, identification and characterization of materials, creating gas phase ions from the analyte atoms or molecules, separating the ions according to their mass-to-charge ratio and measuring the abundance of the ions.
Applications of mass spectrometry, include instrumentation principles, design, and demonstration, chemical kinetics, mechanisms of ionization, theory of ion fragmentation, cluster ions, potential energy surfaces, and modeling, studies of thermodynamic properties, ion spectroscopy, structures and chemical properties of gas-phase ions. Mass Spectrometry application subjects include structural elucidation, biopolymer sequencing, development or validation of new methodology, proteomics, environmental and forensic measurements.
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|This page was last updated on 18thSepÂ 2015|