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St. Ambrose University is a private, coeducational, liberal arts university affiliated with the Roman Catholic Diocese of Davenport.It was established in 1882. It is located in a residential area of Davenport, Iowa, United States. t. Ambrose was founded as a seminary and school of commerce for young men in 1882. It owes its beginning to the first bishop of Davenport, The Most Reverend John McMullen, DD, who founded it under the auspices of the Diocese of Davenport. The affiliation remains strong today.