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The Center for Microbial Oceanography: Research and Education (C-MORE) was established in August 2006 as a National Science Foundation (NSF) sponsored Science and Technology Center. The center is designed to facilitate a more comprehensive understanding of the biological and ecological diversity of marine micro-organisms. Life has its origins in the sea: the first living things were microbes. Marine microbes are the most abundant life forms on Earth, and everything about them is extraordinarily diverse: their structures, their genomes, their physiologies, and their ecological interactions with each other and with the rest of life on the planet. As a global research information center working across disciplines, C-MORE brings together teams of experts—scientists, educators, and community members—who usually have little opportunity to interact, facilitating the creation and dissemination of a new understanding of the critically important role of marine microbes in global habitability. The center’s mission and unifying vision is expressed in the motto: Linking Genomes to Biomes.