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IITRI was formed in 1936 as the Armour Research Foundation (ARF), and was renamed IITRI in 1963. Initially, ARF was formed to support the research endeavours of faculty members from the Armour Institute of Technology, forerunner to the Illinois Institute of Technology (IIT). IITRI is headquartered on the IIT campus in Chicago, but operates as an independent, not-for-profit organization. Between its founding in 1936 and 2000, IITRI developed research operations in approximately two dozen locations across the United States. In 2002, IITRI became entirely focused on the life sciences. All other science and engineering divisions were spun off into Alion Science and Technology, a separate employee-owned corporation. Since 2002, research at IITRI has been entirely focused on biomedical research, with particular emphasis on pre-clinical toxicology, safety evaluations, and drug discovery and development. In 2006, IITRI formed Technology Research, Inc. (TRI), as a wholly owned subsidiary in which research programs that fall outside of IITRIs not-for-profit charter can be conducted. The IITRI staff grew to approximately 1700 employees who performed research and development programs with an annual research budget exceeding $200 M per year. Historically, as a major national science research centre, work involved both unclassified and classified (secret) research. Research and development programs explored as an engineering think tank over the decades have involved many areas of science, including applied physics, high energy physics, upper atmosphere research (aeronomy), nuclear physics, nuclear attack survival, numerical and computer simulations, electron microscopes and microscopy, police technologies, military, luminescence, aerosols, spacecraft thermal protective coatings, material effects by solar radiation, energy work, and mining engineering. The invention of the modern cellphone was developed here. Early research into magnetics here would cause the development of early wire recorders (fostering modern tape recording), and later the new field of computer science. Numerous patents over the decades have resulted from work by its researchers, including as an assignee under "IIT Research Institute". Several of its engineer scientists have distinguished themselves as recipients of the National Medal of Technology or the National Medal of Science, in addition to other awards. Current investigations at IITRI are focused on biomedicine as a contract research organization (CRO), with particular emphasis on non-clinical toxicology, inhalation toxicology and technology, microbiology and molecular biology, and drug discovery and development for cancer and infectious diseases. IITRI conducts research programs with particular emphasis on studies to support Investigational New Drug applications and New Drug applications to the U.S. Food and Drug Administration. IITRI currently performs research in five Technical Divisions: Toxicology, Inhalation Toxicology, Microbiology and Molecular Biology, Carcinogenesis and Cancer Chemoprevention, and Drug Discovery.
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