Institute of Molecular and Cellular Biology (IBMC) is a research institute possessed by the National Center for Scientific Research and operated by the University of Strasbourg it consists of consists of the UPR 9002, UPR 3572 and UPR 9022, Research Unit of the CNRS. Moreover, the bringing together of the three Units under one roof leads to the pooling of certain materials and techniques and to the rational development of methodological platforms. UPR 9002 examines the structure-function relationships governing gene expression both in the bacterial world and in archaea and eukaryotes, both translationally and post-transcriptionally. Special attention is paid to the involvement of RNA in various pathologies. Where UPR 9022 Develops, RIDI) uses Drosophila as a model to study the evolution of this innate immune UPR 9021 (Immunology and Therapeutic Chemistry, ICT) is to understand the molecular and cellular foundations of the immune response and its dysfunction with the aim of defining novel therapeutic pathways of immune-intervention targeted in the treatment Of autoimmune, tumor and viral pathologies. The laboratory is based on approaches to immunology, cell and molecular biology, organic chemistry and pharmacology, structure-function studies, physiology, animal experimentation and cell imaging. On November 22, 2016, the Academy of Sciences awarded the Léon Velluz 2016 Grand Prize to Prof. Sylviane Muller. This prize is awarded, regardless of age, position or nationality, to the author of a discovery of organic chemistry or biochemistry relevant to human therapeutics. The laboratory can accommodate students enrolled in masters degrees Molecular and structural biology Lead, Biology of Microorganisms, Cellular and Molecular, and the group concentrates its activity on effector cells and death/survival factors involved in lupus triggering. In this context, we focus on the central role of autoantigen in the pathophysiology of lupus and more particularly on apoptosis-specific post-translational modifications occurring in autoantigens. Our project also concerns the impact of autophagy on the development of lupus pathology in relation with the presentation by antigen-presenting cells of class II antigens to autoreactive T cells.