The Isaac Newton Institute for Mathematical Sciences was opened in July 1992, after four years of careful preparation. For a number of years and a variety of reasons, a need had been felt for a UK national institute in mathematics and theoretical physics. The realisation of this idea became possible with the financial support from Cambridge Colleges, notably St Johns College and Trinity College. The Institute depends upon donations as well as research grants, to support the world class research undertaken by participants in its programmes. The Isaac Newton Institute for Mathematical Sciences is a national and international visitor research institute. It runs research programmes on selected themes in mathematics and the mathematical sciences with applications over a wide range of science and technology. It attracts leading mathematical scientists from the UK and overseas to interact in research over an extended period. It is known as a world famous place for research in the mathematical sciences with a reputation for efficient management and a warm welcome for visitors. Since the Institute opened, 27 Fields Medallists, 9 Nobel Laureates, 23 winners of a Wolf Prize and 12 winners of the Abel Prize have attended Institute programmes. The Institute runs scientific programmes varying in length from 4 weeks to 6 months. At any particular time there are typically 2 programmes running, each with up to 20 participants working at the Institute. INI is a creative collaborative space which is occupied by up to fifty mathematical scientists at any one time (and many more when there is a workshop). Scientific programmes are selected by an international Scientific Steering Committee, and oversight of the management of the Institute is in the hands of a Management Committee.