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Lab for Translational Research is a laboratory dedicated to cancer patient care, through development and implementation of innovative tumor genotyping technologies. The basic mission of the Translational Research Laboratory is to identify the right drugs based on susceptible molecular alterations offers the hope of improving cancer treatment success on a case-by-case basis by personalized genomic testing as an important component. The Translational Research Laboratory is located on the main hospital campus. We have incorporated the latest technologies to offer moderate- to high-throughput tumor genotyping analyses that reveal mutations in critical cancer genes, abnormalities in cancer gene copy number and structural gene alterations. Emphasis is placed on specific abnormalities that are critical to sustaining and driving the carcinogenic process, thereby providing rationale for incorporating a new generation of targeted therapeutic interventions. The Cancer Center and Pathology Department have jointly developed this laboratory as a culmination of our experiences integrating clinical research with patient care. A strategy that is currently being explored to maximize efficacy of novel therapies in clinical trials is enrollment of patients based on an underlying genetic fingerprint that is most likely to compliment the drug’s actions. The Translational Research Laboratory is working to develop prescreening assays to identify the most relevant patient group and reduce the use of therapies that have little chance of success in a particular individual.
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