The Laboratory of Cellular and Molecular Biology (LCMB) deals with the study of signal transduction mechanisms that control normal cell growth and, when altered, lead to malignant transformation.The mission of LCMB remains focused on performing cutting-edge, world-class research in this field of biology, and important discoveries continue. They focus on defining signaling components and the relationship of signaling to cellular growth and death, transcriptional regulation, mitosis, cellular differentiation and organogenesis, cell adhesion, motility and chemotaxis are more complex topics under investigation. Alterations in signaling leading to oncogenesis, unregulated growth and metastasis are also studied. In all cases the goal LCMB hopes to achieve is outstanding, innovative and high-impact science.
The Laboratory is also a center for graduate training and is staffed by research groups specializing in biophotonics, cell biology, molecular and developmental biology and neurobiology. Faculty members continue to receive substantial national and international recognition for their research.
Specific projects of the laboratory focus on a range of topics, including (1) the nuclear transport of transcription factors, nuclear kinases, steroid hormone receptors, and replication factors that serve a critical regulatory function; (2) the initial events of steroid hormone action, with an emphasis on glucocorticoid receptors; (3) the molecular mechanisms of insulin resistance and glucose-sensing in the pancreas (as part of type 1 and type 2 diabetes); (4) the causes and consequences of repeat expansion in Fragile X syndrome and Friedreich’s ataxia; and (5) the role of O-linked N-acetylglucosamine (O-linked GlcNAc) and its enzymes in diabetes.
The following is the list of scholars from Laboratory of Cell and Molecular Biology who contributed and/or serves as editors for one or more OMICS International journals and conferences