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Laboratory of Malaria Immunology and Vaccinology

The Laboratory of Malaria Immunology and Vaccinology (LMIV) aims to conduct the research relevant to malaria immunology and vaccine development, to pursue novel vaccine concepts, to produce prototype malaria vaccines, and to conduct early-phase clinical trials of promising vaccine candidates. Major research areas include enhancing the basic understanding of malaria pathogenesis and immunity in humans, developing strategies for anti-infection, anti-disease, and transmission-blocking vaccines, production and formulating the antigens suitable for human testing, developing assays and performing animal trials that define the potential for protection, conducting clinical trials to test vaccines in the United States and in malaria endemic areas, establishing scientific collaborations and obtain outside funding to accelerate the program. Together, the discovery sections and Production Unit form a research and testing enterprise that can rapidly translate ideas into proof of concept trials and then capture basic information about human immunity and responses to infection during human clinical trials.

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