The Royal Devon and Exeter NHS Foundation Trust runs Royal Devon and Exeter Hospital, Honeylands Children's Centre (for specialist assessment and support for children with special needs and their families), the Exeter Mobility Centre (providing orthotics, prosthetics, wheelchairs and special seating), and the Mardon Neuro-Rehabilitation Centre. The trust's application for NHS Foundation Trust status was approved in December 2003 and the trust became an NHS Foundation Trust on 1 April 2004, making it one of the first in the country to achieve this status.
In October 2014 it was reported that the Trust was not meeting the government target for 85% of cancer patients to be treated within 62 days of being referred by their GP. The Trust said it was due to increasing demand for complex surgery, and that treatment was only delayed if "clinically appropriate.
The trust makes a significant contribution to world class research and development which improves the quality, experience and effectiveness of healthcare. The RD&E has a track record for piloting new ways of working and patient care for the Department of Health and the National Institute for Innovation, before it is rolled out across the NHS.