The St. Anna Childrens Cancer Research Institute (CCRI) started its operations in 1988 from St. Anna Children’s Hospital located in Vienna, Austria. Since then, it went on to become the largest pediatric cancer centre in Austria. Cancer in children also called as pediatric cancer is a rare case accounts to 1% of all human cancers and chances of occurrence are 1 in 500. It is different from cancers seen in adults. The main focus of the centre has been ‘Therapy Optimization Studies (TOS)’ and is dedicated to improve diagnosis and treatment strategies for cancers in children and adolescents through extensive basic, translational and clinical research in exclusive areas of pediatric oncology to provide optimized treatment to young patients. CCRI works in close collaboration with St. Anna Children’s Hospital and other pediatric centres in the country and the world to achieve quality outcomes. CCRI’s research areas include: Leukaemias, Solid Tumours, Immunology, Molecular Microbiology, and Clinical Research.