The Yale-Griffin Prevention Research Centre (PRC) was established in 1998 through a grant from the Centres for Disease Control (CDC) which is a part of the CDC’s Prevention Research Centres having a network of 26 academic research centres based in 24 states across the U.S. Each Prevention Research Centre is represented by an academic/community partnership which is collaborated with community partners, federal, state, and local health and education agencies, and other universities. Prevention Research Centre is intended to serve as a model for other communities across the country. Also, conducts other community-based and clinical research projects with funding from the CDC and other sources, community-based work with the New Haven neighbourhoods is conducted by Community Alliance for Research and Engagement (CARE), based out of the Yale School of Public Health and Southern Connecticut State University’s School of Health and Human Services. The main objectives of PRC are to advance health promotion and disease prevention in Connecticut by identifying and responding to community health priorities. To engage the community in public health research and practice. To develop an efficient system for assessing community health on an annual basis using both existing and new survey instruments so that progress toward Healthy People 2010 goals can be reliably measured. PRC also provide tailored interventions for the underserved, and contribute to improved allocation of community resources to eliminate existing disparities. It will also create educational and research opportunities in community health for public health students, preventive medicine residents, and community members and to disseminate successful interventions to the benefit of other communities nationwide.